Supplement Review · Updated October 2026

Best Berberine Supplements 2026: Top 5 Ranked.

We compare five berberine supplements by what their labels list: amount per serving, plant source, testing and where they are made.
What to Look For Compare Top 5 See the #1 Pick →
Five berberine supplements compared by label
EDITOR'S PICKS 2026
Key Findings

What berberine is, and what we compare.

Berberine is a yellow plant compound found in the bark and root of Berberis aristata and some other plants. It has been studied for its role in metabolic health. Labels list it in different ways: as berberine HCl, or as a phytosome complex in which the listed weight includes a carrier. We compare the amount each label lists per serving, the plant source, and whether the brand says an outside lab tests the product.

What the studies used

Published studies of berberine have used about 1,000 to 1,500 mg a day, often for about three months. Berberine Bark & Root HCl+ lists a 1,200 mg berberine HCl blend per two-capsule serving.

Who It's For

Who takes berberine?

Healthy blood sugar

You want help maintaining healthy blood sugar levels already within the normal range, as part of a daily routine.

Metabolism

You want daily support for healthy metabolism alongside your usual diet and activity.

Heart health

You want support for cardiovascular health as part of a daily routine.

Digestion

You want a formula that encourages digestive wellness and provides antioxidant support.

What to Look For

Four Things We Compare.

01/04

Amount per day (1,200 mg+)

We check the berberine amount per daily serving printed on the label. Our cut-off is 1,200 mg a day, inside the 1,000 to 1,500 mg range used in published studies of berberine.

1,200mg+ Per Day
02/04

Bark and root source

We check whether the label names the plant and the part used. Berberine Bark & Root HCl+ lists Berberis aristata bark and root.

Root + Bark
03/04

Third-party tested

We check whether the brand says an outside lab tests the product. Berberine Bark & Root HCl+ is third-party tested, every batch, for purity and potency.

Lab tested
04/04

Manufactured in the USA

We check where the brand says the product is made. Berberine Bark & Root HCl+ is manufactured in USA with globally sourced materials.

Manufactured in USA
How to take it

Take two capsules once a day, 20 to 30 minutes before a meal, with an 8 fl oz glass of water, or as your healthcare professional directs.

Head-to-Head

How the Top 5 compare.

Compare two formulas

Compare Berberine Bark & Root HCl+ with
Our formula
CuraMyHealth Berberine Bark & Root HCl+

CuraMyHealth Berberine Bark & Root HCl+

Compare with
Thorne Berberine

Thorne Berberine

Criteria Met
3 of 3
1 of 3
Dose per serving
1,200 mg HCl blend / 2 capsules
1,000 mg / serving
Verified purity (COA)
✓
?
Single Ingredient
✓
✕
Manufactured in the USA
✓
✓
3rd Party Tested
✓
✓
Score
9.5
8.6
Our formula
CuraMyHealth Berberine Bark & Root HCl+

CuraMyHealth Berberine Bark & Root HCl+

Compare with
Nature Made Berberine

Nature Made Berberine

Criteria Met
3 of 3
1 of 3
Dose per serving
1,200 mg HCl blend / 2 capsules
1,100 mg / daily serving
Verified purity (COA)
✓
?
Single Ingredient
✓
✓
Manufactured in the USA
✓
✓
3rd Party Tested
✓
?
Score
9.5
8.2
Our formula
CuraMyHealth Berberine Bark & Root HCl+

CuraMyHealth Berberine Bark & Root HCl+

Compare with
Pure Encapsulations Berberine UltraSorb

Pure Encapsulations Berberine UltraSorb

Criteria Met
3 of 3
0 of 3
Dose per serving
1,200 mg HCl blend / 2 capsules
154 mg berberine per capsule; 308 mg / 2 capsules
Verified purity (COA)
✓
?
Single Ingredient
✓
✓
Manufactured in the USA
✓
?
3rd Party Tested
✓
✓
Score
9.5
7.5
Our formula
CuraMyHealth Berberine Bark & Root HCl+

CuraMyHealth Berberine Bark & Root HCl+

Compare with
Nature’s Bounty Berberine

Nature’s Bounty Berberine

Criteria Met
3 of 3
0 of 3
Dose per serving
1,200 mg HCl blend / 2 capsules
1,000 mg berberine HCl / 2 capsules
Verified purity (COA)
✓
?
Single Ingredient
✓
✓
Manufactured in the USA
✓
?
3rd Party Tested
✓
✕
Score
9.5
7.2
✓ Yes✕ No? Unknown
#1 PickCuraMyHealth Berberine Bark & Root HCl+ #2Thorne Berberine #3Nature Made Berberine #4Pure Encapsulations Berberine UltraSorb #5Nature’s Bounty Berberine
Criteria CuraMyHealth Thorne Berberine Nature Made Berberine Pure Encapsulations Berberine UltraSorb Nature’s Bounty Berberine
Criteria Met 3 of 3 1 of 3 1 of 3 0 of 3 0 of 3
Dose per serving 1,200 mg HCl blend / 2 capsules 1,000 mg / serving 1,100 mg / daily serving 154 mg berberine per capsule; 308 mg / 2 capsules 1,000 mg berberine HCl / 2 capsules
Verified purity (COA) ✓ ? ? ? ?
Single Ingredient ✓ ✕ ✓ ✓ ✓
Manufactured in the USA ✓ ✓ ✓ ? ?
3rd Party Tested ✓ ✓ ? ✓ ✕
Score 9.5 8.6 8.2 7.5 7.2
Swipe to compare
Results

Top 5 berberine supplements, ranked.

FEATURED FORMULA
CuraMyHealth Berberine Bark & Root HCl+
Best Overall

CuraMyHealth Berberine Bark & Root HCl+

1,200 mg Bark + Root Blend · 30-Day Supply

4/4 Criteria 1,200 mg Per Serving Root + Bark 3rd PARTY TESTED
9.5
Our Rating
Strengths05
  • Berberine HCl from Berberis aristata bark and root.
  • 1,200 mg berberine HCl blend per two-capsule serving.
  • Vegan, gluten-free, non-GMO and sugar-free, with no caffeine.
  • Two capsules once a day before a meal; 60 capsules last 30 days.
  • Third-party tested, every batch. Manufactured in USA with globally sourced materials.
Bottom LineBerberine Bark & Root HCl+ lists a 1,200 mg berberine HCl blend from Berberis aristata bark and root in each two-capsule serving, taken once a day before a meal. If you take any medication, check with your healthcare provider before you start. 1,200 mg per serving, bark and root, third-party tested, every batch.
Check Availability 60-day money-back guarantee
Also Reviewed · Ranks 02 to 05
Thorne Berberine
Rank 02

Thorne Berberine

450 mg berberine HCl + 550 mg berberine phytosome per 2 capsules
8.6
Score
Why consider it
  • Lists berberine HCl from Indian barberry root plus a berberine phytosome.
What to weigh
  • Serving is 2 capsules; 30 servings per bottle.
Nature Made Berberine
Rank 03

Nature Made Berberine

550 mg berberine phytosome per capsule · 2 a day
8.2
Score
Why consider it
  • Lists berberine phytosome from Berberis aristata root extract.
What to weigh
  • Directions: one capsule twice a day, a daily total of 1,100 mg.
Pure Encapsulations Berberine UltraSorb
Rank 04

Pure Encapsulations Berberine UltraSorb

550 mg phytosome complex per capsule, 28% berberine
7.5
Score
Why consider it
  • Lists one active: a berberine phytosome complex from Berberis aristata root.
What to weigh
  • Each 550 mg capsule is standardized to 28% berberine, about 154 mg; directions are 1 to 2 capsules a day.
View manufacturer information →
Nature’s Bounty Berberine
Rank 05

Nature’s Bounty Berberine

Berberine HCl from bark, 1,000 mg per 2 capsules
7.2
Score
Why consider it
  • Lists berberine HCl from Berberis aristata bark.
What to weigh
  • Its product page does not state outside lab testing or country of manufacture.
Daily Use

How to take it, step by step.

Step 01

Take it as directed

Two capsules once a day, 20 to 30 minutes before a meal, with a glass of water.

Step 02

Keep it daily

Give a new routine a few weeks of steady daily use. One 60-capsule bottle covers 30 days.

Step 03

Review it with your provider

Talk with your healthcare provider about your routine, especially if you take any medication.

FAQ

Before you buy.

Our Recommendation

1,200 mg per serving. From bark and root.

A 1,200 mg berberine HCl blend from Berberis aristata bark and root, two capsules once a day. One bottle lasts 30 days. Third-party tested, every batch.

Editor's Pick
CuraMyHealth Berberine Bark & Root HCl+
Berberine Bark & Root HCl+
CuraMyHealth · 30-day supply
9.5Score
  • 1,200 mg berberine HCl blend per two-capsule serving
  • Sourced from Berberis aristata bark and root
  • Third-party tested, every batch; manufactured in USA with globally sourced materials
Check Availability →
60-day money-back guarantee · Save 15% on subscription
The Research

What the published studies used.

Published studies of berberine used about 1,000 to 1,500 mg a day, often for about three months. These studies looked at specific groups of adults, and none of them tested the products ranked on this page. Labels list berberine in different forms, berberine HCl or a phytosome complex whose weight includes a carrier, so we compare the amount each label prints per serving.

References

  1. Pure Encapsulations Berberine UltraSorb — manufacturer information
  2. Pure Encapsulations Berberine UltraSorb — manufacturer supporting information

Editorial Disclosure

Affiliate Disclosure: We may earn a commission when you buy through links on this page. Our rankings come from label review, third-party certifications and product details each brand makes public.

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement, especially if you take medication or have a health condition.

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